Quick answer: PDRN (polynucleotides) is a skin-repair ingredient made from purified DNA fragments of Korean wild salmon, and REJURAN is the best-known professional brand built around it. PDRN works by reinforcing your skin’s own barrier and signaling it to regenerate — improving texture, pore appearance, tone, hydration, and firmness over a series of treatments. It’s the fastest-growing regenerative skin category in the world right now. You may have seen alarming videos of REJURAN being injected under the eyes with a syringe — that’s one way to use it, but it is not how we use it at VHB. We deliver REJURAN as a mesotherapy treatment channeled in with microneedling during a facial, with numbing first, so it’s comfortable, controlled, and recovery is minimal. Same Korean technology. Very different experience.

Why is everyone suddenly talking about salmon DNA?

Two things happened at once. PDRN became the breakout regenerative ingredient of 2025–2026 because it targets exactly what skincare in 2026 cares about: barrier health, resilience, and real skin quality rather than a quick cosmetic cover-up. And REJURAN went viral — not always in a flattering way. The clips most people have seen show a provider injecting product in a grid of tiny needle-sticks under the eyes. It looks intense, and honestly, done that way it can be.

That viral version is one delivery method. It is not the only one, and it’s not ours.

How VHB does REJURAN (and why it doesn’t have to hurt)

REJURAN’s professional protocol is a mesotherapy treatment — the product is designed to be absorbed into the upper layers of skin, and REJURAN’s own protocol calls for it to be applied and then channeled in with a microneedling device, not deposited deep with a syringe. That distinction is the whole point. At VHB, our Master Esthetician Stacy Wu incorporates REJURAN the way it was designed to be delivered:

• We numb first. A numbing layer goes on and absorbs for 10–20 minutes before anything begins.
• We channel, not jab. The REJURAN serum is infused using a microneedling device set to the appropriate depth for your skin — comfortable and controlled, not deep under-eye injections.
• We finish calm. Treatments end with cooling and soothing so you leave refreshed, not raw.
• We diagnose first. REJURAN is never the default. We read your barrier, tone, and texture and decide together whether it’s right.

Same direct-from-Korea technology the dermatology clinics use — in master-esthetician hands, on your terms.

What REJURAN actually does

According to REJURAN’s clinical materials, the active ingredient is 1% hydrolyzed DNA (PDRN) extracted from Korean wild salmon using a patented DNA Optimizing Technology (DOT™). REJURAN reports the fragments are engineered to be roughly 670× smaller than your pore size for better absorption, and cites PDRN safety and efficacy data across 2,000+ scientific journals and 7 medical centers worldwide.

In plain language, the treatment is designed to:

• Reinforce and regenerate the skin barrier
• Support your own collagen and elastin production
• Improve skin texture and tone
• Minimize the appearance of pores
• Soften the look of fine lines and wrinkles
• Help balance oil and moisture (and reduce excess sebum)
• Boost hydration, glow, and firmness

The Skin Booster pairs PDRN with hyaluronic acid (for water-binding and plumping) and four amino acids — glycine, L-lysine, L-leucine, and L-proline — the building blocks behind roughly 80% of the collagen in your dermis. There’s also a Tone-Up Booster that adds a brightening cocktail of vitamin C (ascorbic acid), glutathione, and tranexamic acid for dullness and uneven tone.

Is it right for you?

REJURAN sits squarely in the lane we love: results that improve your actual skin, not a frozen or “done” look.

• If you know your K-beauty: this is glass skin, grown up. PDRN is the clinical engine behind that luminous, even, barrier-healthy look.
• If you want refreshed-not-altered: this is non-injectable-style anti-aging that reads as “well-rested,” not “work done.” No filler, no frozen movement — just better skin quality over a few sessions.

Take it home: our favorite PDRN products

A great in-studio treatment deserves homecare that keeps the momentum going. These are the PDRN products we carry and reach for:

• Dr. Ellyan PDRN Mask — on sale now, 20% off through July 5. Our go-to summer barrier reset: PDRN for repair plus niacinamide to keep summer oil and redness in check. Ten minutes, two to three times a week.
• Dr. REJURALL PDRN Cream (K-pharmacy) — a daily PDRN-infused barrier cream for everyday repair and calm, not just treatment days.
• REJURAN Lash Serum — a PDRN-powered lash-conditioning serum for fuller-looking, healthier lashes.

Frequently asked questions

What is PDRN and where does it come from?
PDRN (polynucleotides) is made from purified DNA fragments of Korean wild salmon, whose DNA is highly compatible with human skin. It’s used to support skin repair, barrier function, and regeneration.

Does REJURAN hurt?
It depends entirely on how it’s delivered. The deep under-eye injections you’ve seen go viral can be uncomfortable. At VHB we deliver REJURAN as a numbed, microneedling-channeled mesotherapy treatment, which most clients find very tolerable.

Is REJURAN the same as Botox or filler?
No. Botox relaxes muscle and filler adds volume. REJURAN’s PDRN works on skin quality — barrier, texture, tone, and firmness — so results look like better skin, not a changed face.

How many sessions will I need?
PDRN works cumulatively. Most people do a short series spaced a few weeks apart, then maintain. We’ll map your plan at a diagnostic visit.

Can I just use PDRN at home?
Topical PDRN products (like a PDRN mask or cream) are a great way to support your barrier between treatments, but they work differently from a professional mesotherapy treatment. Many clients use both.

Ready to try PDRN the comfortable way?

Book a diagnostic visit with Stacy and we’ll tell you honestly whether REJURAN is right for your skin — and how to get the most from it. We’re in Brea (Mon/Wed/Thu/Fri/Sat) and Costa Mesa / Newport Beach (Sun & Tue). 

And while you’re here, the Dr. Ellyan PDRN mask is 20% off through July 5.